منابع مشابه
A "slow" protein folds quickly in the end.
Until just a few years ago, it was not clear whether it would be possible to fold proteins using all-atom molecular dynamics simulations with explicit solvent molecules, despite the insights that these simulations had yielded into other biological problems. This was not just because of the computational challenge of reaching folding time scales, typically microseconds to seconds or longer, but ...
متن کاملBilateral Choroidal Folds in a Diabetic Patient
Abstract In this presentation, a case of bilateral choroidal folds in patient with diabetic retinopathy was reported. By our knowledge, this case presentation is the first report of choroidal folds in diabetic retinopathy, which bilateral symmetric and horizontal folds arranged in macula. The thick choroid that is developed in diabetics may be a cause of these folds but the source of differenc...
متن کاملProtein folds in the worm genome.
We survey the protein folds in the worm genome, using pairwise and multiple-sequence comparison methods (i.e. FASTA and PSI-blast). Overall, we find that approximately 250 folds match approximately 8000 domains in approximately 4500 ORFs, about 32 matches per fold involving a quarter of the total worm ORFs. We compare the folds in the worm genome to those in other model organisms, in particular...
متن کاملProtein folds and protein folding.
The classification of protein folds is necessarily based on the structural elements that distinguish domains. Classification of protein domains consists of two problems: the partition of structures into domains and the classification of domains into sets of similar structures (or folds). Although similar topologies may arise by convergent evolution, the similarity of their respective folding pa...
متن کاملProtein folds and functions.
BACKGROUND The recent rapid increase in the number of available three-dimensional protein structures has further highlighted the necessity to understand the relationship between biological function and structure. Using structural classification schemes such as SCOP, CATH and DALI, it is now possible to explore global relationships between protein fold and function, something which was previousl...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2013
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1303539110